Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters.

نویسندگان

  • Chung Whan Lee
  • Seo-Jung Han
  • Scott C Virgil
  • Brian M Stoltz
چکیده

An improved method for the asymetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.

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عنوان ژورنال:
  • Tetrahedron

دوره 71 22  شماره 

صفحات  -

تاریخ انتشار 2015